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Abstract
Grant Number: 1R01EB005847-01 Project Title: CRCNS: Analysis of Multi-Neuronal Data: Cortical Plasticity During Learning
PI Information: Name Title KASS, ROBERT E. kass@stat.cmu.edu PROFESSOR AND HEAD Abstract: DESCRIPTION (provided by applicant): Multiple-electrode neuronal recording has created tremendous new opportunities for gaining insight into the neural substrate of behavior, and it has made possible the construction of brain-controlled robotic devices. A crucial problem is to describe evolution of neuronal activity during learning, which is of interest not only from the point of view of basic science, but also because knowledge of the changes that occur while a subject learns a task is necessary for the construction of reliable neural prosthetic algorithms. This research will develop and adapt statistical methods for analysis of multiple-electrode data from a series of experiments aimed at understanding the evolution of cortical activity in several areas of the brain while a monkey learns hand movement tasks. The results will lead to improvements in brain-controlled robotic devices for neural prostheses and, thus, will likely benefit people paralyzed by head or spinal cord trauma, amputees, and those with severe deficits caused by diseases such as stroke, amyotrophic lateral sclerosis, cerebral palsy, or multiple sclerosis.
Public Health Relevance:
This Public Health Relevance is not available.Thesaurus Terms:
brain electrical activity, computational neuroscience, computer data analysis, learning, neural plasticity
computer program /software, computer system design /evaluation, nervous system prosthesis
animal data
Institution: CARNEGIE-MELLON UNIVERSITY 5000 FORBES AVE PITTSBURGH, PA 15213 Fiscal Year: 2005 Department: STATISTICS Project Start: 01-SEP-2005 Project End: 30-JUN-2009 ICD: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING IRG: ZRG1