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Abstract

Grant Number:	1F32DK068996-01
Project Title:	Chronic Kidney Disease with Benign Prostatic Hyperplasia

PI Information:	Name	Email	Title
	RULE, ANDREW D.	rule.andrew@mayo.edu

Abstract: DESCRIPTION (provided by applicant): Benign Prostatic Hyperplasia (BPH) and Chronic Kidney Disease (CKD) are both common medical conditions in aging men. Prior studies looking at the association between these two diseases have been case series of 3PH patients at the time of intervention, often confounded by acute urinary retention. BPH and its urinary tract infection (UTI) complication may be under-appreciated risk factors for the development of CKD. This study will use data from a community-based prospective longitudinal cohort study of 2311 men followed for complications of BPH over 13 years. Using both a linear mixed effects regression model and a logistic regression model, the relationship between a baseline BPH surrogate measure and/or UTI history with the development of CKD will be assessed. Baseline BPH surrogate measures are a symptom score, peak urinary flow rate, residual urine volume, and prostate size. Development of CKD will be assessed through biennial longitudinal changes in serum creatinine. Known risk factors for CKD such as diabetes mellitus and hypertension will be abstracted from the medical record and adjusted for as potential confounders. Based on preliminary data, a significant association between BPH surrogate measures and CKD is expected. This study will clarify whether earlier assessment and intervention in BPH is warranted to prevent CKD.

Public Health Relevance:
This Public Health Relevance is not available.

Thesaurus Terms:
benign prostate hyperplasia, chronic disease /disorder, kidney disorder, longitudinal human study
aging, creatinine, prostate preneoplastic state, serum, urinary tract infection
clinical research, human subject, male, postdoctoral investigator

Institution:	MAYO CLINIC COLL OF MEDICINE, ROCHESTER
	200 1ST ST SW
	ROCHESTER, MN 55905
Fiscal Year:	2004
Department:
Project Start:	01-SEP-2004
Project End:	31-AUG-2005
ICD:	NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
IRG:	ZRG1

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