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Abstract
Grant Number: 1R01AG022272-01 Project Title: Incremental Learning Algorithm for Early Diagnosis
PI Information: Name Title CLARK, CHRISTOPHER MICHAEL. chris.clark@uphs.upenn.edu ASSOCIATE PROFESSOR OF NEUROLOGY Abstract: DESCRIPTION (provided by applicant): The following is an abridged version of the project submitted with the original NSF/NIH proposal. The original project summary is included along with the project description. Alzheimer's disease (AD) affects an estimated 4 million Americans, making it a major public health concern. While the positive predictive value of clinical diagnosis is around 93% at university research clinics, most patients are evaluated by community healthcare providers where the accuracy of the diagnosis remains uncertain. Meanwhile, active development of pathologically targeted medications requires an accurate diagnosis at the earliest stage possible. To have a meaningful impact on healthcare, the diagnosis procedure must be inexpensive, non-invasive and available to community physicians. Therefore, this study specially aims: (1) to develop and optimize an automated classification system for AD diagnosis that can learn incrementally from data as it becomes available, that can estimate its own confidence as well as the severity of the disease, and that can be implemented in hardware as a low-cost portable device; (2) to determine the sensitivity, specificity and positive predictive value of the proposed system in correctly categorizing subjects as demented or normal. The proposed method combines clinical, mathematical and computational techniques of EEG analysis, multiresolution wavelet analysis and neural network (NN) based ensemble classification, to detect the earliest neurodegenerative changes of AD. While changes in ERPs have been used to identify various neurological disorders, their traditional visual and statistical evaluations have been ineffective in detecting such neurodegenerative changes. Multiresolution wavelet analysis (MWA) represents a promising method for concurrent temporal and spectral analysis of non-stationary ERP signals, whereas NN based ensemble classifiers provide a powerful automated classification tool. The classification system will be optimized to incrementally learn additional information that becomes available over a long period of time. The classifier decisions will then be combined for an automated identification of the subject's clinical classification, as well as the severity of the disease, if the disease is predicted to exist. A statistical analysis of classification results will also be performed to estimate the confidence of the decision.
Public Health Relevance:
This Public Health Relevance is not available.Thesaurus Terms:
computational neuroscience, diagnosis design /evaluation, early diagnosis, nervous system disorder diagnosis
Alzheimer's disease, aging, brain electrical activity, cognition, computer program /software, diagnosis quality /standard, diagnostic test, electroencephalography, evoked potential, mathematics, neural degeneration
clinical research, human subject
Institution: UNIVERSITY OF PENNSYLVANIA 3451 Walnut Street PHILADELPHIA, PA 19104 Fiscal Year: 2003 Department: NEUROLOGY Project Start: 15-MAR-2003 Project End: 28-FEB-2006 ICD: NATIONAL INSTITUTE ON AGING IRG: ZRG1