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Abstract
Grant Number: 1R01NS046065-01 Project Title: Mechanistic model of multisensory postural control
PI Information: Name Title JEKA, JOHN J. jjeka@umd.edu ASSOCIATE PROFESSOR Abstract: DESCRIPTION (provided by applicant): The long-term goal of this research is to understand how the nervous system fuses information from multiple sensory systems for the control of upright stance. The ability to select and reweight alternative orientation references adaptively is considered a critical factor for postural control in patient and elderly populations. Despite the importance of multisensory reweighting, little is known about how it is achieved. We have developed a new experimental paradigm that simultaneously manipulates two sensory inputs (vision and touch) to probe the properties of multisensory integration. In parallel, we have developed a unique two-step modeling approach using time series techniques and mechanistic models to determine which characteristics of postural sway can: i) be attributed to estimation or control; and ii) distinguish different mechanisms of estimation used for multisensory reweighting. Here we focus on modeling the process of multisensory reweighting in changing sensory environments. The goal is to develop a mechanistic model that will explicitly link underlying physiological subsystems to postural control. Future work will address patient populations with similar techniques to determine the basis of their balance deficits.
Public Health Relevance:
This Public Health Relevance is not available.Thesaurus Terms:
neural information processing, posture, sensory mechanism
auditory feedback, balance, biomechanics, body movement, mathematical model, model design /development, proprioception /kinesthesia, touch, vestibular pathway, vision, visual feedback
clinical research, human subject, young adult human (21-34)
Institution: UNIVERSITY OF MARYLAND COLLEGE PK CAMPUS 3112 LEE BUILDING COLLEGE PARK, MD 207425141 Fiscal Year: 2002 Department: KINESIOLOGY Project Start: 30-SEP-2002 Project End: 31-AUG-2006 ICD: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE IRG: ZRG1