Version 2.5.2.0

Abstract

Grant Number:	1R01NS046057-01
Project Title:	CRCNS: Modeling and Analysis of Neuronal Circuits

PI Information:	Name	Email	Title
	IWASAKI, TETSUYA	iwasaki@virginia.edu

Abstract: DESCRIPTION (provided by applicant): The broad aim for this project is to enhance the understanding of biological information processing mechanisms. The immediate goals are to uncover the fundamental roles of sensory feedback mechanisms in the neuronal control of animal locomotion and to establish mathematical models that predict the dynamical behavior of and supply missing information about the biological system. More specifically, the aims are to I) perform biophysical and physiological experiments on leech preparations to collect neuronal and mechanical input/output data needed for quantitative models, II) develop a mathematical model of the neuronal control system for leech swimming that includes sensory feedback, III) predict the effects of sensory feedback through numerical simulations of the model, and IV) test these predictions through physiological experiments on leech preparations. This project employs the Lur'e model for neuronal dynamics, recently developed by the Pl, as a basis for the modeling of neurodynamic feedback control system of leech swimming. The class of Lur'e systems has been extensively studied in the systems and control discipline and thus a variety of mathematical analysis tools are available. The project develops dynamical models (differential equations) of the leech locomotion control system, consisting of the central oscillator, muscle actuation by motoneurons, body-fluid interactions, and sensory feedback from stretch receptors, through parameter identifications based on experimental observations. Physiological experiments will be conducted on dissected and intact leech preparations to obtain explicit values for model parameters and to test hypotheses generated by experiments performed on the model. The collaborative engineering--neurophysiological research proposed here is part of a broad effort to discover general principles for the neuronal control of animal movements. Because of the functional similarity, insights gained from the proposed research on leech swimming can be expected to increase our understanding of the neuronal control of rhythmic movements generally. Potential applications of the knowledge to be generated include insights into the cause of walking disability and development of rehabilitation methodologies.

Public Health Relevance:
This Public Health Relevance is not available.

Thesaurus Terms:
mathematical model, model design /development, neural information processing, neurophysiology, sensorimotor system, sensory feedback
invertebrate locomotion, motor neuron, neural conduction, neuromuscular function, neuroregulation, stretch receptor
Hirudinea

Institution:	UNIVERSITY OF VIRGINIA CHARLOTTESVILLE
	BOX 400195
	CHARLOTTESVILLE, VA 229044195
Fiscal Year:	2002
Department:	MECHANICAL AND AEROSPACE ENGR
Project Start:	30-SEP-2002
Project End:	31-AUG-2006
ICD:	NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
IRG:	ZRG1

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