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Abstract
Grant Number: 5U19CA081888-05 Project Title: BASAL CELL CARCINOMA CHEMOPREVENTION IN BCNS PATIENTS
PI Information: Name Title EPSTEIN, ERVIN H. eepstein@chori.org RESEARCH DERMATOLOGIST, CLINICAL PROFESS Abstract: DESCRIPTION: (Applicant's Description) Basal Cell Carcinomas (BCCs) are the commonest human cancer and are of increasing incidence, due in part to increased recreational sunlight exposure. During the past two years, the fundamental molecular defect apparently underlying the aberrant behavior of these tumor cells has been uncovered; all BCCs have abnormal regulation of the hedgehog signaling pathway. Patients with the basal cell nevus syndrome (BCNS) are susceptible to developing multiple basal cell carcinomas because they inherit one defective allele of the PTC gene, which encodes a protein that hampers hedgehog signaling. Mice hemizygous for a functioning ptc gene, like BCNS patients with the same genotype, are highly susceptible to the development of BCCs, and these are induced by the relevant environmental insult-ultraviolet light. This project will utilize the growing knowledge of HCC signaling aberrations, the murine BCC model, and the chemopreventive effects of tea extracts to develop agents efficacious in preventing BCC carcinogenesis in mice and man and will investigate the mechanisms underlying such efficacy.
Public Health Relevance:
This Public Health Relevance is not available.Thesaurus Terms:
basal cell carcinoma, cancer prevention, chemoprevention
Institution: UNIVERSITY OF CALIFORNIA SAN FRANCISCO 3333 California St., Ste 315 SAN FRANCISCO, CA 941430962 Fiscal Year: 2003 Department: DERMATOLOGY Project Start: 21-JUL-1999 Project End: 30-JUN-2006 ICD: NATIONAL CANCER INSTITUTE IRG: ZCA1