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Abstract

Grant Number:	5R37CA063677-09
Project Title:	GENES CONTROLLING NEOPLASIA OF THE INTESTINAL EPITHELIUM

PI Information:	Name	Email	Title
	DOVE, WILLIAM F.	dove@oncology.wisc.edu	PROFESSOR OF ONCOLOGY AND MEDICAL GENETI

Abstract: The Min mouse strain develops multiple intestinal neoplasms on sensitive genetic background. It is heterozygous for a nonsense allele of the Adenomatous polyposis coli gene of the mouse, Apc. We first shall aim to settle controversial issues concerning the strict adherence of adenoma formation to the one-locus Knudson model and the clonality of early tumors. Then, we shall explore the involvement of several candidate molecular systems in the Min phenotype, including the Wingless signaling pathway. Our work culminates in developing a sensitized genetic screen for mutant modifiers of the Min phenotypes. This screen, novel in mammalian cancer genetics, may identify a series of factors acting in this tumor lineage and in the tumor-bearing host.

Public Health Relevance:
This Public Health Relevance is not available.

Thesaurus Terms:
adenomatous polyp, intestine neoplasm, molecular oncology, neoplasm /cancer genetics, neoplastic transformation
antisense nucleic acid, cell growth regulation, cellular oncology, cytosine, disease /disorder model, fibroma, gastrointestinal epithelium, gene deletion mutation, gene expression, genetic mapping, genetic susceptibility, heterozygote, methyltransferase, phenotype, transforming growth factor
genetic technique, laboratory mouse, transgenic animal

Institution:	UNIVERSITY OF WISCONSIN MADISON
	21 N. Park Street, Suite 6401
	MADISON, WI 537151218
Fiscal Year:	2002
Department:	ONCOLOGY
Project Start:	22-SEP-1993
Project End:	31-DEC-2002
ICD:	NATIONAL CANCER INSTITUTE
IRG:	MEP

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