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Abstract
Grant Number: 5R01CA067264-04 Project Title: RISK FACTORS AND BIOMARKERS FOR IN SITU BREAST CANCER
PI Information: Name Title NEWCOMB, POLLY A. pnewcomb@fhcrc.org MEMBER AND ACTING HEAD Abstract: Heightened utilization of mammography has resulted in dramatic increases in the occurrence of breast carcinoma in situ (BCIS), yet the public health significance of these lesions remains controversial. We propose a multi-center population-based case-control study to evaluate risk factors and biomarkers of breast carcinoma in situ. We will examine the influence of established risk factors for invasive breast carcinoma on BCIS as well as newly identified risk factors, such as alcohol consumption, postmenopausal hormone use, and physical activity. We will evaluate risk factors for BCIS and its major subtypes, lobular carcinoma in situ (LCIS), ductal carcinoma in situ (DCIS), and the aggressive DCIS subtype (comedo- type DCIS). Thus, we will distinguish etiologic factors, including potentially modifiable exposures, that may be related to specific subtypes of biologic significance. In addition, we will be able to compare BCIS risk factors with those identified in our current case-control study of invasive breast cancer. Our unique approach will allow an investigation of risk factors related to tumors of apparently incremental malignant significance. This study will utilize our existing and highly successful consortium of population-based, case-control studies of breast cancer. In the proposed study, we will interview over a 36-month period, 1575 women with breast carcinoma in situ identified from the WI, MA, and NH state cancer registries. For comparison, about 2205 population-based controls will be randomly selected from drivers' license lists and Medicare beneficiary files in each state. This approach will permit the evaluation of two control groups: women with a recent mammographic history, and general population controls. Consenting subjects will participate in a telephone interview. The proposed study, which includes sufficient numbers of BCIS subtypes of disparate malignant potential, provides a unique opportunity to evaluate biomarkers in relation to early disease development. Thus, we propose to evaluate the relationship between BCIS (and its subtypes) to p53 mutations NAT2 genotype. These biomarkers are related to invasive breast cancer; our design will allow us to evaluate the extent to which these markers are related to LCIS, DCIS, and the comedo-type DCIS. In addition, we will evaluate the relation between these biomarkers and exposures; this approach may elucidate risk factors involved in early disease developments. The findings of this study may have important implications for breast cancer prevention and intervention. In addition, this study will establish the foundation for follow-up studies.
Public Health Relevance:
This Public Health Relevance is not available.Thesaurus Terms:
biomarker, breast neoplasm, cancer risk, human population study, neoplasm /cancer genetics, neoplasm /cancer invasiveness
age at pregnancy, alcoholic beverage consumption, body physical activity, gene /environment interaction, gene expression, gene mutation, genetic marker, hormone therapy, molecular oncology, postmenopause, tobacco abuse, tumor suppressor gene, women's health
clinical research, human genetic material tag, human subject, interview, polymerase chain reaction, single strand conformation polymorphism, statistics /biometry
Institution: UNIVERSITY OF WISCONSIN MADISON 21 N. Park Street, Suite 6401 MADISON, WI 537151218 Fiscal Year: 1999 Department: LABORATORY FOR CANCER RESEARCH Project Start: 01-JUN-1996 Project End: 28-FEB-2002 ICD: NATIONAL CANCER INSTITUTE IRG: EDC