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Scope Note:

intracellular knots or clumps of neurofibrils seen in various parts of the brain in Alzheimer's disease; composed of dense arrays of paired helical filaments (neurofilaments and microtubules) and incorporating the following proteins: intermediate filaments, medium and high molecular weight neurofilaments, microtubule associated proteins, map2 and tau, actin, and ubiquitins.

Term Number:

2042-3269